PTGDR Back

prostaglandin D2 receptor (DP)

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of PTGDR
The protein encoded by this gene is a G-protein-coupled receptor. It has been shown to function as a prostanoid DP receptor. The activity of this receptor is mainly mediated by G-S proteins that stimulate adenylate cyclase resulting in an elevation of intracellular cAMP and Ca2+. Knockout studies in mice suggest that the ligand of this receptor, prostaglandin D2 (PGD2), functions as a mast cell-derived mediator to trigger asthmatic responses.

Community Annotation of PTGDR Add / Edit PTGDR: Annotations

No community annotations yet for PTGDR.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

PTGDR is highly significantly mutated in
(none)
PTGDR is significantly mutated in
(none)
PTGDR is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for PTGDR