PTF1A Back

pancreas specific transcription factor, 1a

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of PTF1A

This gene encodes a protein that is a component of the pancreas transcription factor 1 complex (PTF1) and is known to have a role in mammalian pancreatic development. The protein plays a role in determining whether cells allocated to the pancreatic buds continue towards pancreatic organogenesis or revert back to duodenal fates. The protein is thought to be involved in the maintenance of exocrine pancreas-specific gene expression including elastase 1 and amylase. Mutations in this gene cause cerebellar agenesis and loss of expression is seen in ductal type pancreas cancers.

Community Annotation of PTF1A Add / Edit PTF1A: Annotations

No community annotations yet for PTF1A.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

PTF1A is highly significantly mutated in
(none)
PTF1A is significantly mutated in
(none)
PTF1A is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


Mutation list for PTF1A