NCBI Description of PTF1A
|This gene encodes a protein that is a component of the pancreas transcription factor 1 complex (PTF1) and is known to have a role in mammalian pancreatic development. The protein plays a role in determining whether cells allocated to the pancreatic buds continue towards pancreatic organogenesis or revert back to duodenal fates. The protein is thought to be involved in the maintenance of exocrine pancreas-specific gene expression including elastase 1 and amylase. Mutations in this gene cause cerebellar agenesis and loss of expression is seen in ductal type pancreas cancers.|
Community Annotation of PTF1A Add / Edit PTF1A: Annotations
No community annotations yet for PTF1A.
• "Mouse over" a mutation to see details.
Click on a tumor type to see its full list of significant genes.