PSRC1 Back

proline/serine-rich coiled-coil 1

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of PSRC1

This gene encodes a proline-rich protein. Studies of this gene and the related mouse gene suggest that this gene is regulated by p53 and may participate in p53-mediated growth suppression. The encoded protein may function as a microtubule destabilizing protein that controls spindle dynamics and mitotic progression by recruiting and regulating microtubule depolymerases. At least one genetic variation in this gene has been associated with decreased serum levels of low-density lipoprotein cholesterol. Alternatively spliced transcript variants encoding different isoforms have been described.

Community Annotation of PSRC1 Add / Edit PSRC1: Annotations

No community annotations yet for PSRC1.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


PSRC1 is highly significantly mutated in
PSRC1 is significantly mutated in
PSRC1 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for PSRC1