PSMB6 Back

proteasome (prosome, macropain) subunit, beta type, 6

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of PSMB6
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. The encoded protein is a member of the proteasome B-type family, also known as the T1B family, and is a 20S core beta subunit in the proteasome. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Community Annotation of PSMB6 Add / Edit PSMB6: Annotations

No community annotations yet for PSMB6.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

PSMB6 is highly significantly mutated in
(none)
PSMB6 is significantly mutated in
(none)
PSMB6 is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for PSMB6