PSMB4 Back

proteasome (prosome, macropain) subunit, beta type, 4

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of PSMB4

The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit.

Community Annotation of PSMB4 Add / Edit PSMB4: Annotations

No community annotations yet for PSMB4.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


PSMB4 is highly significantly mutated in
PSMB4 is significantly mutated in
PSMB4 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for PSMB4