PRX Back

periaxin

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of PRX
This gene encodes a protein involved in peripheral nerve myelin upkeep. The encoded protein contains 2 PDZ domains which were named after PSD95 (post synaptic density protein), DlgA (Drosophila disc large tumor suppressor), and ZO1 (a mammalian tight junction protein). Two alternatively spliced transcript variants have been described for this gene which encode different protein isoforms and which are targeted differently in the Schwann cell. Mutations in this gene cause Charcot-Marie-Tooth neuoropathy, type 4F and Dejerine-Sottas neuropathy.

Community Annotation of PRX Add / Edit PRX: Annotations

No community annotations yet for PRX.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

PRX is highly significantly mutated in
(none)
PRX is significantly mutated in
(none)
PRX is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for PRX