PRSS8 Back

protease, serine, 8

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NCBI Description of PRSS8

This gene encodes a trypsinogen, which is a member of the trypsin family of serine proteases. This enzyme is highly expressed in prostate epithelia and is one of several proteolytic enzymes found in seminal fluid. The proprotein is cleaved to produce a light chain and a heavy chain which are associated by a disulfide bond. It is active on peptide linkages involving the carboxyl group of lysine or arginine.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

PRSS8 is highly significantly mutated in
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PRSS8 is significantly mutated in
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PRSS8 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


Mutation list for PRSS8