PRSS12 Back

protease, serine, 12 (neurotrypsin, motopsin)

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NCBI Description of PRSS12
This gene encodes a member of the trypsin family of serine proteases. Studies in mouse suggest that the encoded enzyme may be involved in structural reorganizations associated with learning and memory. The enzyme is also expressed in Leydig cells in the testis, but its function in this tissue is unknown. Defects in this gene are a cause of mental retardation autosomal recessive type 1 (MRT1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.

Community Annotation of PRSS12 Add / Edit PRSS12: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

PRSS12 is highly significantly mutated in
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PRSS12 is significantly mutated in
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PRSS12 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for PRSS12