PRRG1 Back

proline rich Gla (G-carboxyglutamic acid) 1

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NCBI Description of PRRG1
This gene encodes a vitamin K-dependent, gamma-carboxyglutamic acid (Gla)-containing, single-pass transmembrane protein. This protein contains a Gla domain at the N-terminus, preceded by a propeptide sequence required for post-translational gamma-carboxylation of specific glutamic acid residues by a vitamin K-dependent gamma-carboxylase. The C-terminus is proline-rich containing PPXY and PXXP motifs found in a variety of signaling and cytoskeletal proteins. This gene is highly expressed in the spinal cord. Several alternatively spliced transcript variants have been found for this gene.

Community Annotation of PRRG1 Add / Edit PRRG1: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

PRRG1 is highly significantly mutated in
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PRRG1 is significantly mutated in
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PRRG1 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for PRRG1