PRPSAP2 Back

phosphoribosyl pyrophosphate synthetase-associated protein 2

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NCBI Description of PRPSAP2
This gene encodes a protein that associates with the enzyme phosphoribosylpyrophosphate synthetase (PRS). PRS catalyzes the formation of phosphoribosylpyrophosphate which is a substrate for synthesis of purine and pyrimidine nucleotides, histidine, tryptophan and NAD. PRS exists as a complex with two catalytic subunits and two associated subunits. This gene encodes a non-catalytic associated subunit of PRS. Alternate splicing results in multiple transcript variants.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

PRPSAP2 is highly significantly mutated in
(none)
PRPSAP2 is significantly mutated in
(none)
PRPSAP2 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for PRPSAP2