PRPS2 Back

phosphoribosyl pyrophosphate synthetase 2

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NCBI Description of PRPS2
This gene encodes a phosphoribosyl pyrophosphate synthetase that plays a central role in the synthesis of purines and pyrimidines. The encoded protein catalyzes the synthesis of 5-phosphoribosyl 1-pyrophosphate from ATP and D-ribose 5-phosphate. Alternate splicing results in multiple transcript variants.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

PRPS2 is highly significantly mutated in
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PRPS2 is significantly mutated in
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PRPS2 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for PRPS2