PRPS1L1 Back

phosphoribosyl pyrophosphate synthetase 1-like 1

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NCBI Description of PRPS1L1
This intronless gene is specifically expressed in the testis, and encodes a protein that is highly homologous to the two subunits of phosphoribosylpyrophosphate synthetase encoded by human X-linked genes, PRPS1 and PRPS2. These enzymes convert pyrimidine, purine or pyridine bases to the corresponding ribonucleoside monophosphates. In vitro transcription/translation and site-directed mutagenesis studies indicate that translation of this mRNA initiates exclusively at a non-AUG (ACG) codon.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

PRPS1L1 is highly significantly mutated in
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PRPS1L1 is significantly mutated in
(none)
PRPS1L1 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for PRPS1L1