PRPF18 Back

PRP18 pre-mRNA processing factor 18 homolog (S. cerevisiae)

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NCBI Description of PRPF18

Pre-mRNA splicing occurs in 2 sequential transesterification steps. The protein encoded by this gene is found to be essential for the catalytic step II in pre-mRNA splicing process. It is found in the spliceosome, and contains seven WD repeats, which function in protein-protein interactions. This protein has a sequence similarity to the yeast splicing factor Prp18.

Community Annotation of PRPF18 Add / Edit PRPF18: Annotations

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


PRPF18 is highly significantly mutated in
PRPF18 is significantly mutated in
PRPF18 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for PRPF18