PROZ Back

protein Z, vitamin K-dependent plasma glycoprotein

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NCBI Description of PROZ
This gene encodes a liver vitamin K-dependent glycoprotein that is synthesized in the liver and secreted into the plasma. The encoded protein plays a role in regulating blood coagulation by complexing with protein Z-dependent protease inhibitor to directly inhibit activated factor X at the phospholipid surface. Deficiencies in this protein are associated with an increased risk of ischemic arterial diseases and fetal loss. Mutations in this gene are the cause of protein Z deficiency. Alternate splicing results in multiple transcript variants.

Community Annotation of PROZ Add / Edit PROZ: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

PROZ is highly significantly mutated in
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PROZ is significantly mutated in
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PROZ is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for PROZ