PROX1 Back

prospero homeobox 1

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of PROX1
The protein encoded by this gene is a member of the homeobox transcription factor family. Members of this family contain a homeobox domain that consists of a 60-amino acid helix-turn-helix structure that binds DNA and RNA. The protein encoded by this gene is conserved across vertebrates and may play an essential role during development. Altered levels of this protein have been reported in cancers of different organs, such as colon, brain, blood, breast, pancreas, liver and esophagus. Alternative splicing results in multiple transcript variants.

Community Annotation of PROX1 Add / Edit PROX1: Annotations

No community annotations yet for PROX1.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

PROX1 is highly significantly mutated in
(none)
PROX1 is significantly mutated in
(none)
PROX1 is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for PROX1