PROS1 Back

protein S (alpha)

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of PROS1

This gene encodes a vitamin K-dependent plasma protein that functions as a cofactor for the anticoagulant protease, activated protein C (APC) to inhibit blood coagulation. It is found in plasma in both a free, functionally active form and also in an inactive form complexed with C4b-binding protein. Mutations in this gene result in autosomal dominant hereditary thrombophilia. An inactive pseudogene of this locus is located at an adjacent region on chromosome 3. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.

Community Annotation of PROS1 Add / Edit PROS1: Annotations

No community annotations yet for PROS1.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

PROS1 is highly significantly mutated in
(none)
PROS1 is significantly mutated in
(none)
PROS1 is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


Mutation list for PROS1