PROP1 Back

PROP paired-like homeobox 1

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of PROP1
This gene encodes a paired-like homeodomain transcription factor in the developing pituitary gland. Expression occurs prior to and is required for expression of pou domain transcription factor 1, which is responsible for pituitary development and hormone expression. Mutations in this gene have been associated with combined pituitary hormone deficiency-2 as well as deficiencies in luteinizing hormone, follicle-stimulating hormone, growth hormone, prolactin, and thyroid-stimulating hormone.

Community Annotation of PROP1 Add / Edit PROP1: Annotations

No community annotations yet for PROP1.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

PROP1 is highly significantly mutated in
(none)
PROP1 is significantly mutated in
(none)
PROP1 is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for PROP1