PROM1 Back

prominin 1

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of PROM1
This gene encodes a pentaspan transmembrane glycoprotein. The protein localizes to membrane protrusions and is often expressed on adult stem cells, where it is thought to function in maintaining stem cell properties by suppressing differentiation. Mutations in this gene have been shown to result in retinitis pigmentosa and Stargardt disease. Expression of this gene is also associated with several types of cancer. This gene is expressed from at least five alternative promoters that are expressed in a tissue-dependent manner. Multiple transcript variants encoding different isoforms have been found for this gene.

Community Annotation of PROM1 Add / Edit PROM1: Annotations

No community annotations yet for PROM1.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

PROM1 is highly significantly mutated in
(none)
PROM1 is significantly mutated in
(none)
PROM1 is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for PROM1