PRODH Back

proline dehydrogenase (oxidase) 1

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NCBI Description of PRODH

This gene encodes a mitochondrial protein that catalyzes the first step in proline degradation. Mutations in this gene are associated with hyperprolinemia type 1 and susceptibility to schizophrenia 4 (SCZD4). This gene is located on chromosome 22q11.21, a region which has also been associated with the contiguous gene deletion syndromes, DiGeorge and CATCH22. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Community Annotation of PRODH Add / Edit PRODH: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

PRODH is highly significantly mutated in
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PRODH is significantly mutated in
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PRODH is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


Mutation list for PRODH