PRKDC Back

protein kinase, DNA-activated, catalytic polypeptide

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NCBI Description of PRKDC

This gene encodes the catalytic subunit of the DNA-dependent protein kinase (DNA-PK). It functions with the Ku70/Ku80 heterodimer protein in DNA double strand break repair and recombination. The protein encoded is a member of the PI3/PI4-kinase family.

Community Annotation of PRKDC Add / Edit PRKDC: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

PRKDC is highly significantly mutated in
(none)
PRKDC is significantly mutated in
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PRKDC is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


Mutation list for PRKDC