PRKCZ Back

protein kinase C, zeta

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of PRKCZ
Protein kinase C (PKC) zeta is a member of the PKC family of serine/threonine kinases which are involved in a variety of cellular processes such as proliferation, differentiation and secretion. Unlike the classical PKC isoenzymes which are calcium-dependent, PKC zeta exhibits a kinase activity which is independent of calcium and diacylglycerol but not of phosphatidylserine. Furthermore, it is insensitive to typical PKC inhibitors and cannot be activated by phorbol ester. Unlike the classical PKC isoenzymes, it has only a single zinc finger module. These structural and biochemical properties indicate that the zeta subspecies is related to, but distinct from other isoenzymes of PKC. Alternative splicing results in multiple transcript variants encoding different isoforms.

Community Annotation of PRKCZ Add / Edit PRKCZ: Annotations

No community annotations yet for PRKCZ.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

PRKCZ is highly significantly mutated in
(none)
PRKCZ is significantly mutated in
(none)
PRKCZ is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for PRKCZ