protein kinase, AMP-activated, beta 2 non-catalytic subunit

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of PRKAB2

The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. It is highly expressed in skeletal muscle and thus may have tissue-specific roles.

Community Annotation of PRKAB2 Add / Edit PRKAB2: Annotations

No community annotations yet for PRKAB2.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


PRKAB2 is highly significantly mutated in
PRKAB2 is significantly mutated in
PRKAB2 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for PRKAB2