PRIM2 Back

primase, DNA, polypeptide 2 (58kDa)

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NCBI Description of PRIM2

The replication of DNA in eukaryotic cells is carried out by a complex chromosomal replication apparatus, in which DNA polymerase alpha and primase are two key enzymatic components. Primase, which is a heterodimer of a small subunit and a large subunit, synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication. The protein encoded by this gene is the large, 58 kDa primase subunit.

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


PRIM2 is highly significantly mutated in
PRIM2 is significantly mutated in
PRIM2 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for PRIM2