PRICKLE2 Back

prickle homolog 2 (Drosophila)

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NCBI Description of PRICKLE2
This gene encodes a homolog of Drosophila prickle. The exact function of this gene is not known, however, studies in mice suggest that it may be involved in seizure prevention. Mutations in this gene are associated with progressive myoclonic epilepsy type 5. Sequence Note: removed 1 base from the 5' end that did not align to the reference genome assembly.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

PRICKLE2 is highly significantly mutated in
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PRICKLE2 is significantly mutated in
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PRICKLE2 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for PRICKLE2