PRG2 Back

proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)

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NCBI Description of PRG2
The protein encoded by this gene is the predominant constituent of the crystalline core of the eosinophil granule. High levels of the proform of this protein are also present in placenta and pregnancy serum, where it exists as a complex with several other proteins including pregnancy-associated plasma protein A (PAPPA), angiotensinogen (AGT), and C3dg. This protein may be involved in antiparasitic defense mechanisms as a cytotoxin and helminthotoxin, and in immune hypersensitivity reactions. It is directly implicated in epithelial cell damage, exfoliation, and bronchospasm in allergic diseases. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Community Annotation of PRG2 Add / Edit PRG2: Annotations

No community annotations yet for PRG2.
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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

PRG2 is highly significantly mutated in
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PRG2 is significantly mutated in
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PRG2 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for PRG2