PREX1 Back

phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1

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NCBI Description of PREX1
The protein encoded by this gene acts as a guanine nucleotide exchange factor for the RHO family of small GTP-binding proteins (RACs). It has been shown to bind to and activate RAC1 by exchanging bound GDP for free GTP. The encoded protein, which is found mainly in the cytoplasm, is activated by phosphatidylinositol-3,4,5-trisphosphate and the beta-gamma subunits of heterotrimeric G proteins.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

PREX1 is highly significantly mutated in
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PREX1 is significantly mutated in
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PREX1 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for PREX1