PREPL Back

prolyl endopeptidase-like

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NCBI Description of PREPL
The protein encoded by this gene belongs to the prolyl oligopeptidase subfamily of serine peptidases. Mutations in this gene have been associated with hypotonia-cystinuria syndrome, also known as the 2p21 deletion syndrome. Several alternatively spliced transcript variants encoding either the same or different isoforms have been described for this gene.

Community Annotation of PREPL Add / Edit PREPL: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

PREPL is highly significantly mutated in
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PREPL is significantly mutated in
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PREPL is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for PREPL