PRDX4 Back

peroxiredoxin 4

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NCBI Description of PRDX4

The protein encoded by this gene is an antioxidant enzyme and belongs to the peroxiredoxin family. The protein is localized to the cytoplasm. Peroxidases of the peroxiredoxin family reduce hydrogen peroxide and alkyl hydroperoxides to water and alcohol with the use of reducing equivalents derived from thiol-containing donor molecules. This protein has been found to play a regulatory role in the activation of the transcription factor NF-kappaB.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

PRDX4 is highly significantly mutated in
(none)
PRDX4 is significantly mutated in
(none)
PRDX4 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


Mutation list for PRDX4