PRDM2 Back

PR domain containing 2, with ZNF domain

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of PRDM2
This tumor suppressor gene is a member of a nuclear histone/protein methyltransferase superfamily. It encodes a zinc finger protein that can bind to retinoblastoma protein, estrogen receptor, and the TPA-responsive element (MTE) of the heme-oxygenase-1 gene. Although the functions of this protein have not been fully characterized, it may (1) play a role in transcriptional regulation during neuronal differentiation and pathogenesis of retinoblastoma, (2) act as a transcriptional activator of the heme-oxygenase-1 gene, and (3) be a specific effector of estrogen action. Multiple transcript variants encoding different isoforms have been found for this gene.

Community Annotation of PRDM2 Add / Edit PRDM2: Annotations

No community annotations yet for PRDM2.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

PRDM2 is highly significantly mutated in
(none)
PRDM2 is significantly mutated in
(none)
PRDM2 is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for PRDM2