PRCC Back

papillary renal cell carcinoma (translocation-associated)

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of PRCC

This gene encodes a protein that may play a role in pre-mRNA splicing. Chromosomal translocations (X;1)(p11;q21) that result in fusion of this gene to TFE3 (GeneID 7030) have been associated with papillary renal cell carcinoma. A PRCC-TFE3 fusion protein is expressed in affected carcinomas and is likely associated with altered gene transactivation. This fusion protein has also been associated with disruption of the cell cycle.

Community Annotation of PRCC Add / Edit PRCC: Annotations

No community annotations yet for PRCC.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

PRCC is highly significantly mutated in
(none)
PRCC is significantly mutated in
(none)
PRCC is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


Mutation list for PRCC