PRAME Back

preferentially expressed antigen in melanoma

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NCBI Description of PRAME
This gene encodes an antigen that is predominantly expressed in human melanomas and that is recognized by cytolytic T lymphocytes. It is not expressed in normal tissues, except testis. This expression pattern is similar to that of other CT antigens, such as MAGE, BAGE and GAGE. However, unlike these other CT antigens, this gene is also expressed in acute leukemias. Five alternatively spliced transcript variants encoding the same protein have been observed for this gene.

Community Annotation of PRAME Add / Edit PRAME: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

PRAME is highly significantly mutated in
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PRAME is significantly mutated in
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PRAME is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for PRAME