PRAM1 Back

PML-RARA regulated adaptor molecule 1

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NCBI Description of PRAM1
The protein encoded by this gene is similar to FYN binding protein (FYB/SLAP-130), an adaptor protein involved in T cell receptor mediated signaling. This gene is expressed and regulated during normal myelopoiesis. The expression of this gene is induced by retinoic acid and is inhibited by the expression of PML-RARalpha, a fusion protein of promyelocytic leukemia (PML) and the retinoic acid receptor-alpha (RARalpha). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.

Community Annotation of PRAM1 Add / Edit PRAM1: Annotations

No community annotations yet for PRAM1.
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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

PRAM1 is highly significantly mutated in
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PRAM1 is significantly mutated in
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PRAM1 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for PRAM1