PPP4R1 Back

protein phosphatase 4, regulatory subunit 1

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of PPP4R1
This gene encodes one of several alternate regulatory subunits of serine/threonine protein phosphatase 4 (PP4). The protein features multiple HEAT repeats. This protein forms a complex with PP4RC. This complex may have a distinct role from other PP4 complexes, including regulation of HDAC3 (Zhang et al., PMID: 15805470). There is also a transcribed pseudogene on chromosome 20. Alternative splicing results in multiple transcript variants.

Community Annotation of PPP4R1 Add / Edit PPP4R1: Annotations

No community annotations yet for PPP4R1.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

PPP4R1 is highly significantly mutated in
(none)
PPP4R1 is significantly mutated in
(none)
PPP4R1 is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for PPP4R1