PPP2R5B Back

protein phosphatase 2, regulatory subunit B', beta isoform

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NCBI Description of PPP2R5B
The product of this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a beta isoform of the regulatory subunit B56 subfamily.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

PPP2R5B is highly significantly mutated in
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PPP2R5B is significantly mutated in
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PPP2R5B is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for PPP2R5B