PPP2R5A Back

protein phosphatase 2, regulatory subunit B', alpha isoform

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NCBI Description of PPP2R5A
The product of this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes an alpha isoform of the regulatory subunit B56 subfamily. Alternative transcript variants encoding distinct isoforms have been found for this gene.

Community Annotation of PPP2R5A Add / Edit PPP2R5A: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

PPP2R5A is highly significantly mutated in
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PPP2R5A is significantly mutated in
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PPP2R5A is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for PPP2R5A