PPP2R1B Back

protein phosphatase 2 (formerly 2A), regulatory subunit A, beta isoform

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of PPP2R1B

This gene encodes a constant regulatory subunit of protein phosphatase 2. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. This gene encodes a beta isoform of the constant regulatory subunit A. Mutations in this gene have been associated with some lung and colon cancers. Alternatively spliced transcript variants have been described.

Community Annotation of PPP2R1B Add / Edit PPP2R1B: Annotations

No community annotations yet for PPP2R1B.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


PPP2R1B is highly significantly mutated in
PPP2R1B is significantly mutated in
PPP2R1B is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for PPP2R1B