protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform

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NCBI Description of PPP2CA

This gene encodes the phosphatase 2A catalytic subunit. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. This gene encodes an alpha isoform of the catalytic subunit.

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


PPP2CA is highly significantly mutated in
PPP2CA is significantly mutated in
PPP2CA is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for PPP2CA