PPP1R1B Back

protein phosphatase 1, regulatory (inhibitor) subunit 1B (dopamine and cAMP regulated phosphoprotein, DARPP-32)

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NCBI Description of PPP1R1B
This gene encodes a bifunctional signal transduction molecule. Dopaminergic and glutamatergic receptor stimulation regulates its phosphorylation and function as a kinase or phosphatase inhibitor. As a target for dopamine, this gene may serve as a therapeutic target for neurologic and psychiatric disorders. Multiple transcript variants encoding different isoforms have been found for this gene.

Community Annotation of PPP1R1B Add / Edit PPP1R1B: Annotations

No community annotations yet for PPP1R1B.
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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

PPP1R1B is highly significantly mutated in
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PPP1R1B is significantly mutated in
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PPP1R1B is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for PPP1R1B