PPP1R15B Back

protein phosphatase 1, regulatory (inhibitor) subunit 15B

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NCBI Description of PPP1R15B

PPP1R15B promotes dephosphorylation of the transcription initiation factor EIF2-alpha (EIF2S1; MIM 603907) through recruitment of protein phosphatase-1 (PP1) catalytic subunits (see MIM 176875) (Harding et al., 2009 [PubMed 19181853]).[supplied by OMIM, Feb 2010].

Community Annotation of PPP1R15B Add / Edit PPP1R15B: Annotations

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


PPP1R15B is highly significantly mutated in
PPP1R15B is significantly mutated in
PPP1R15B is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for PPP1R15B