PPP1R14A Back

protein phosphatase 1, regulatory (inhibitor) subunit 14A

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NCBI Description of PPP1R14A
The protein encoded by this gene belongs to the protein phosphatase 1 (PP1) inhibitor family. This protein is an inhibitor of smooth muscle myosin phosphatase, and has higher inhibitory activity when phosphorylated. Inhibition of myosin phosphatase leads to increased myosin phosphorylation and enhanced smooth muscle contraction. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.

Community Annotation of PPP1R14A Add / Edit PPP1R14A: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

PPP1R14A is highly significantly mutated in
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PPP1R14A is significantly mutated in
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PPP1R14A is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for PPP1R14A