PPP1R13B Back

protein phosphatase 1, regulatory (inhibitor) subunit 13B

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of PPP1R13B
This gene encodes a member of the ASPP (apoptosis-stimulating protein of p53) family of p53 interacting proteins. The protein contains four ankyrin repeats and an SH3 domain involved in protein-protein interactions. ASPP proteins are required for the induction of apoptosis by p53-family proteins. They promote DNA binding and transactivation of p53-family proteins on the promoters of proapoptotic genes. Expression of this gene is regulated by the E2F transcription factor.

Community Annotation of PPP1R13B Add / Edit PPP1R13B: Annotations

No community annotations yet for PPP1R13B.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

PPP1R13B is highly significantly mutated in
(none)
PPP1R13B is significantly mutated in
(none)
PPP1R13B is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for PPP1R13B