PPP1R12B Back

protein phosphatase 1, regulatory (inhibitor) subunit 12B

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of PPP1R12B
Myosin phosphatase is a protein complex comprised of three subunits: a catalytic subunit (PP1c-delta, protein phosphatase 1, catalytic subunit delta), a large regulatory subunit (MYPT, myosin phosphatase target) and small regulatory subunit (sm-M20). Two isoforms of MYPT have been isolated--MYPT1 and MYPT2, the first of which is widely expressed, and the second of which may be specific to heart, skeletal muscle, and brain. Each of the MYPT isoforms functions to bind PP1c-delta and increase phosphatase activity. This locus encodes both MYTP2 and M20. Alternatively spliced transcript variants encoding different isoforms have been identified. Related pseudogenes have been defined on the Y chromosome.

Community Annotation of PPP1R12B Add / Edit PPP1R12B: Annotations

No community annotations yet for PPP1R12B.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

PPP1R12B is highly significantly mutated in
(none)
PPP1R12B is significantly mutated in
(none)
PPP1R12B is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for PPP1R12B