PPP1CB Back

protein phosphatase 1, catalytic subunit, beta isoform

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NCBI Description of PPP1CB
The protein encoded by this gene is one of the three catalytic subunits of protein phosphatase 1 (PP1). PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Mouse studies suggest that PP1 functions as a suppressor of learning and memory. Two alternatively spliced transcript variants encoding distinct isoforms have been observed.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

PPP1CB is highly significantly mutated in
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PPP1CB is significantly mutated in
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PPP1CB is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for PPP1CB