PPM1K Back

protein phosphatase 1K (PP2C domain containing)

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of PPM1K

This gene encodes a member of the PPM family of Mn2+/Mg2+-dependent protein phosphatases. The encoded protein, essential for cell survival and development, is targeted to the mitochondria where it plays a key role in regulation of the mitochondrial permeability transition pore. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.

Community Annotation of PPM1K Add / Edit PPM1K: Annotations

No community annotations yet for PPM1K.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


PPM1K is highly significantly mutated in
PPM1K is significantly mutated in
PPM1K is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for PPM1K