PPM1G Back

protein phosphatase 1G (formerly 2C), magnesium-dependent, gamma isoform

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NCBI Description of PPM1G

The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase is found to be responsible for the dephosphorylation of Pre-mRNA splicing factors, which is important for the formation of functional spliceosome. Studies of a similar gene in mice suggested a role of this phosphatase in regulating cell cycle progression.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

PPM1G is highly significantly mutated in
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PPM1G is significantly mutated in
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PPM1G is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


Mutation list for PPM1G