NCBI Description of PPM1B
|The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase has been shown to dephosphorylate cyclin-dependent kinases (CDKs), and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to cause cell-growth arrest or cell death. Alternative splicing results in multiple transcript variants encoding different isoforms. Additional transcript variants have been described, but currently do not represent full-length sequences.|
Community Annotation of PPM1B Add / Edit PPM1B: Annotations
No community annotations yet for PPM1B.
• "Mouse over" a mutation to see details.
Click on a tumor type to see its full list of significant genes.