PPIF Back

peptidylprolyl isomerase F (cyclophilin F)

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NCBI Description of PPIF
The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. This protein is part of the mitochondrial permeability transition pore in the inner mitochondrial membrane. Activation of this pore is thought to be involved in the induction of apoptotic and necrotic cell death.

Community Annotation of PPIF Add / Edit PPIF: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

PPIF is highly significantly mutated in
(none)
PPIF is significantly mutated in
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PPIF is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for PPIF