PPIE Back

peptidylprolyl isomerase E (cyclophilin E)

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of PPIE
The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. This protein contains a highly conserved cyclophilin (CYP) domain as well as an RNA-binding domain. It was shown to possess PPIase and protein folding activities, and it also exhibits RNA-binding activity. Alternative splicing results in multiple transcript variants. A related pseudogene, which is also located on chromosome 1, has been identified.

Community Annotation of PPIE Add / Edit PPIE: Annotations

No community annotations yet for PPIE.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

PPIE is highly significantly mutated in
(none)
PPIE is significantly mutated in
(none)
PPIE is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for PPIE