PPIB Back

peptidylprolyl isomerase B (cyclophilin B)

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NCBI Description of PPIB
The protein encoded by this gene is a cyclosporine-binding protein and is mainly located within the endoplasmic reticulum. It is associated with the secretory pathway and released in biological fluids. This protein can bind to cells derived from T- and B-lymphocytes, and may regulate cyclosporine A-mediated immunosuppression. Variants have been identified in this protein that give rise to recessive forms of osteogenesis imperfecta.

Community Annotation of PPIB Add / Edit PPIB: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

PPIB is highly significantly mutated in
(none)
PPIB is significantly mutated in
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PPIB is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for PPIB