PPEF2 Back

protein phosphatase, EF-hand calcium binding domain 2

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NCBI Description of PPEF2
This gene encodes a member of the serine/threonine protein phosphatase with EF-hand motif family. The protein contains a protein phosphatase catalytic domain, and at least two EF-hand calcium-binding motifs in its C terminus. Although its substrate(s) is unknown, the encoded protein, which is expressed specifically in photoreceptors and the pineal, has been suggested to play a role in the visual system. This gene shares high sequence similarity with the Drosophila retinal degeneration C (rdgC) gene.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

PPEF2 is highly significantly mutated in
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PPEF2 is significantly mutated in
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PPEF2 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for PPEF2